Human GFAP (7-66) Protein, hFc Tag

The protein has a predicted molecular mass of 32.4 kDa after removal of the signal peptide. The apparent molecular mass of GFAP (7-66) -hFc is approximately 35-55 kDa due to glycosylation. This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms.