Human NOTCH3 Protein, hFc Tag

The protein has a predicted molecular mass of 70.9 kDa after removal of the signal peptide. The apparent molecular mass of NOTCH3-hFc is approximately 70-100 kDa due to glycosylation. This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) .