Human CD74 (73-232) Protein, hFc Tag

The protein has a predicted molecular mass of 44.4 kDa after removal of the signal peptide.The apparent molecular mass of hFc-CD74 (73-232) is approximately 55-70 kDa due to glycosylation. The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta) . Multiple alternatively spliced transcript variants encoding different isoforms have been identified.