Human IL11 Protein, hFc Tag

The protein has a predicted molecular mass of 45.3 kDa after removal of the signal peptide. The apparent molecular mass of IL11-hFc is approximately 55-70 kDa due to glycosylation. The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130) . This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.