Human ROR1 (312-391) Protein, hFc Tag

The protein has a predicted molecular mass of 35.2 kDa after removal of the signal peptide.The apparent molecular mass of hFc- ROR1 (312-391) is approximately 35-55 kDa due to glycosylation. This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms.