Recombinant human BRD4 protein with C-terminal human Fc tag

Expression Host : HEK293 The protein has a predicted molecular mass of 49.61 kDa after removal of the signal peptide. The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t (15,19) (q13, p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described.