Recombinant human IGF-1R protein with C-terminal human Fc tag

Expression Host : HEK293 The protein has a predicted molecular mass of 124.74 kDa after removal of the signal peptide. This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.