Recombinant human 4-1BB protein with C-terminal6Ã-His tag

Expression Host : HEK293 The protein has a predicted molecular mass of 18.1 kDa after removal of the signal peptide. The apparent molecular mass of 4-1BB-His is approximately 25-35 kDa due to glycosylation. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.