Recombinant human CD48 protein with C-terminal human Fc

Expression Host : HEK293 The protein has a predicted molecular mass of 48.5 kDa after removal of the signal peptide.The apparent molecular mass of CD48-hFC is approximately 55-70 kDa due to glycosylation. This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.