Recombinant human PD-1 protein with C-terminal mouse Fc and6Ã-His tag

Expression Host : HEK293 The protein has a predicted molecular mass of 43.5 kDa after removal of the signal peptide. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.