Recombinant human OX40 protein with C-terminal human Fc and6Ã-His tag
Expression Host : HEK293 The protein has a predicted molecular mass of 47.2 kDa after removal of the signal peptide. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.
Product Specifications
Product Name Alternative
TNFRSF4, OX40, CD134, OX40L receptor, ACT35, TXGP1L
Purification
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Components
Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Shipping Conditions
Delivery in 1-2 weeks
Storage Conditions
Store at -80°C for 12 months (Avoid repeated freezing and thawing)
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