Recombinant human GITR protein with C-terminal mouse Fc and6Ã-His tag

Expression Host : HEK293 The protein has a predicted molecular mass of 50-52 kDa after removal of the signal peptide. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25 (+) CD4 (+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.