Recombinant human GITR protein with C-terminal human Fc and6Ã-His tag
Expression Host : HEK293 The protein has a predicted molecular mass of 51-52 kDa after removal of the signal peptide. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25 (+) CD4 (+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Product Specifications
Product Name Alternative
AITR, GITR, TNFRSF18, CD357
Purification
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Components
Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Shipping Conditions
Delivery in 2-4 weeks
Storage Conditions
Store at -80°C for 12 months (Avoid repeated freezing and thawing)
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