CD27 Human, HEK

Source:HEK293 Cells. Physical Appearance:Sterile Filtered colorless solution. ED50 range is = 0.8 ug/ml. Defined by its binding ability in a functional ELISA with Human CD27 Ligand/TNFSF7. CD27 belongs to the TNF-receptor superfamily. CD27 is necessary for initiation and long-term maintenance of T cell immunity. CD27 binds to ligand CD70, and has a crucial role in regulating B-cell activation and immunoglobulin synthesis. The CD27 receptor transduces signals which result in the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 mediate the signaling process of CD27. CD27-binding protein (SIVA), which is a proapoptotic protein, can bind to the CD27 receptor and is believed to have a significant role in the apoptosis induced by CD27. CD27 Human Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain (20-191 a.a) containing a total of 411 amino acids, having a molecular mass of 46.2kDa. CD27 is fused to a 239 amino acid hIgG-His-Tag at C-terminus, and is purified by proprietary chromatographic techniques.