IL1A Canine

Source:Sf9, Baculovirus cells.Physical Appearance:Sterile Filtered colorless solution.Biological ActivityMeasured in a cell proliferation assay using D10.G4.1 mouse helper T cell. The ED50 range = 2 ng/ml.The cytokine IL-1 alpha or hematopoietin 1 is a member to the interleukin 1 family, encoded by the IL1A gene in humans. Essentially Il-1 is in charge of inflammation and the rising of fever and sepsis. In order to disturb the mentioned processes and treatment for diseases, inhibitors for Interleukin 1 alpha are being developed. Neutrophils and macrophages are the main activators of IL-1 alpha, as well as endothelial and epithelial cells. By binding to the il1 receptor it is a major part in the immune response regulation. In the activation process of tumor necrosis factor-alpha the IL1A has a part as well, and has physiological, metabolic and hematopoietic activities.IL1A Canine produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 166 amino acids (109-265 aa) and having a molecular mass of 19.3 kDa.IL1A is fused to a 6 amino acid His tag at C-terminus and purified by proprietary chromatographic techniques.