SIGLEC10 Human
Source: Sf9, Baculovirus cells.Sterile Filtered colorless solution.Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) is a part of the immunoglobulin superfamily that is expressed on eosinophils, B cells, monocytes and neutrophils. SIGLEC10 is an adhesion molecule that mediates sialic-acid dependent binding to cells.SIGLEC10 is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab. Also, it binds to Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24.This binding is modulated by cis interactions of SIGLEC10 with sialated molecules on the same cell.SIGLEC10 Human produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 678 amino acids (17-455 a.a.) and having a molecular mass of 75.6kDa. SIGLEC10 is expressed with a 239 hIgG-His-tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Specifications
Product Name Alternative
SIGLEC10, PRO940, SLG2, SIGLEC-10, Sialic acid-binding Ig-like lectin 10 isoform 3, Siglec-like protein 2.
Purification
Greater than 85.0% as determined by SDS-PAGE.
Components
The SIGLEC10 solution (0.25mg/mL) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Storage Conditions
Amino Acids
Frequently Asked Questions
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