SFRP4 Human, sf9

Source: Sf9, Baculovirus cells.Sterile Filtered colorless solution.Secreted frizzled-related protein 4 (SFRP4) belongs to the SFRP family which contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs serve as soluble modulators of Wnt signaling. SFRP4 may serve as a regulator of adult uterine morphology and function. SFRP4 increases apoptosis during ovulation possibly via modulation of FZ1/FZ4/WNT4 signaling. SFRP4 also has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. SFRP4 is expressed in proliferative endometrium and several types of ovarian, endometrial and Brest tumors. SFRP4 is expressed in mesenchymal cells and in cardiomyocytes. SFRP4 expression in ventricular myocardium correlates with apoptosis related gene expression. SFRP4 is up-regulated in failing myocardium.SFRP4 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 337 amino acids (19-346 a.a.) and having a molecular mass of 38.9kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa) . SFRP4 is expressed with a 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.