CD40 Mouse

Source: Sf9, Baculovirus cells.Sterile Filtered colorless solution.CD40 belongs to the TNF-receptor super family. CD40 has been found to be vital in mediating a wide range of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is accounted to coordinately regulate the expression of CD40 and its ligand, which is significant for homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 and functions as a mediator of the signal transduction. The interaction of CD40 and its ligand is found to be essential for amyloid-beta-induced microglial activation, and therefore is considered to be an early event in Alzheimer disease pathogenesis.CD40 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 180 amino acids (20-193 a.a.) and having a molecular mass of 20.1kDa (Migrates at 18-28kDa on SDS-PAGE under reducing conditions) .