Recombinant Human T-cell surface glycoprotein CD4/sCD4 (C-Fc)

Source : Human Cells; CD4 is an approximately 55 kDa type I transmembrane glycoprotein that is expressed predominantly on thymocytes and a subset of mature T lymphocytes. It is a standard phenotype marker for the identification of T cell populations. Mature human CD4 consists of a 371-amino acid extracellular region containing four immunoglobulin-like domains, a 22-aa transmembrane segment, and a 40-aa cytoplasmic domain. CD4 is expressed along with CD8 on double positive T-cells during their development in the thymus. CD4 binds directly to MHC class-II molecules on antigen presenting cells (10) . This interaction contributes to the formation of the immunological synapse which is focused around the TCR-MHC class II-antigenic peptide interaction. CD4 also functions as a chemotactic receptor for IL-16 and, in human, as a co-receptor for the gp120 surface glycoprotein of HIV-1.