Recombinant Human Neuropilin-1/NRP1 (C-His)

Source : Human 293 Cells; Neuropilin-1, also known as vascular endothelial cell growth factor 165 receptor (VEGF165R), CD304, is a member of the neuropilin family. Neuropilin-1 is a receptor involved in multiple functions, including the development of the cardiovascular system, angiogenesis, the formation of certain neuronal circuits and organogenesis outside the nervous system. It also mediates the chemorepulsant activity of semaphorins. Neuropilin-1 can bind to semaphorin 3A, PLGF-2, VEGF-165, and VEGF-B. Coexpression of Neuropilin-1 with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis.