Recombinant Human Lymphotoxin beta Receptor/LTBR (C-His)

Source : Human 293 Cells; Lymphotoxin-beta receptor (LTBR) is a member of the tumor necrosis factor (TNF) family of receptors. Tumor necrosis factor receptor is a trimeric cytokine receptor that binds tumor necrosis factors. The receptor interacts with an adaptor protein (such as TRADD, TRAF, RIP), which is critical in determining the outcome of the response. LTBR is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, except for T and B lymphocytes. LTBR specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta) . LTBR and its ligand are involved in the development and organization of lymphoid tissue and tranformed cells. Activation of this protein can cause apoptosis. LTBR can also regulate the release of the cytokine interleukin 8. Overexpression of LTBR in HEK293 cells can increase IL-8 promoter activity and lead to IL-8 release. It is also essential for development and organization of the secondary lymphoid organs and chemokine release.