Recombinant Human IL-2RA/CD25 (C-hFc)

Source : Human 293 Cells; Interleukin-2 receptor subunit alpha (IL2RA) is a single-pass type I membrane glycoprotein, contains 2 Sushi (CCP/SCR) domains. IL2RA is expressed on activated T cells and regulatory T cells, and can bind IL2 with low affinity by itself. The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. While homodimeric alpha chains (IL2RA) result in low-affinity receptor, homodimeric beta (IL2RB) chains produce a medium-affinity receptor. CD25 has been previously regarded as an activation marker on dendritic cells. Although both murine and human dendritic cells can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling.