Recombinant Human Sulfamidase/SGSH (C-His)

Source : Human 293 Cells; N-Sulphoglucosamine Sulphohydrolase (SGSH) is a member of the sulfatase family that is involved in the degradation of heparin sulfate (HS) . SGSH catalyzes N-sulfo-D-glucosamine and H2O to D-glucosamine and sulfate. Unlike the HS specific endosulfatases that remove sulfate from internal GlcNAc residues, SGSH removes sulfate group from the non-reducing end glucosamine residues on HS. SGSH leads to mucopolysaccharidosis type 3A (MPS3A), a recessive lysosomal storage disease characterized by neurological dysfunction but relatively mild somatic manifestations.