Recombinant Human IL-3R alpha/CD123 (C-hFc)

Source : Human 293 Cells; CD123, also known as Interleukin-3 receptor subunit alpha, is a glycoprotein that belongs to the type I cytokine receptor family. CD123 is a heterodimer with an alpha and a beta subunit. The alpha subunit alone binds IL-3 with low affinity. The beta subunit does not bind IL-3 by itself but is required for the high-affinity binding of IL-3 to the heterodimeric receptor complex. CD123 induces the proliferation and differentiation of hemopoietic cells including the pluripotent hematopoietic stem cells as well as a variety of lineage-committed cells. CD123 has been identified as a potential immunotherapeutic target due to its overexpression in AML compared with normal hematopoietic stem cells.