Recombinant Human LAIR1 (C-His)

Source : Human 293 Cells; Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) is a type I transmembrane glycoprotein, that belongs to immunoglobulin superfamily and leukocyte-associated inhibitory receptor family. LAIR-1 is expressed on most of the mononuclear cells, including natural killer (NK) cells, B-cells, T-cells, monocytes, and dendritic cells. LAIR-1 plays a role in negatively regulating the cytolytic function of immune cells to prevent lysis of cells recognized as self. Studies predicted that LAIR-1 mediates the inhibitory function based on immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic domain.