Recombinant Human Interleukin-10 Receptor Subunit Alpha/IL-10 Ra (C-6His)

Source: E. coli. MW :25.2kD. Recombinant Human Interleukin-10 Receptor Subunit Alpha is produced by our E. coli expression system and the target gene encoding His22-Asn235 is expressed with a 6His tag at the C-terminus. Interleukin-10 Receptor alpha (IL-10Ra) is a transmembrane glycoprotein member of the class II cytokine receptor family. Mature human IL-10 Ra consists of a 214 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and a 322 aa cytoplasmic domain. Within the ECD, human IL-10 Ra shares 59% aa sequence identity with mouse and rat IL-10Ra. IL-10 Ra is required for mediating the effects of IL-10, a critical molecule in the control of microbial infections, allergic and autoimmune inflammation, and cancer. IL-10Ra is the ligand specific subunit of the IL-10 receptor complex. Noncovalent dimers of IL-10 bind to IL-10 Ra, resulting in the recruitment of IL-10 R beta. Immunosuppressive signal transduction through the IL-10 receptor complex can be inhibited by activation of TLR2, 4, or 9, enabling strengthened immune responses during infection. Polymorphisms of human IL-10 Ra may limit viral immune evasion by retaining full responsiveness to human IL-10 but responding weakly to the cytomegalovirus homolog of IL10.