Recombinant Human Connective Tissue Growth Factor/CTGF/CCN2 (C-Fc)

Source: Human Cells. MW :62.6kD. Recombinant Human CTGF is produced by our Mammalian expression system and the target gene encoding Gln27-Ala349 is expressed with a Fc tag at the C-terminus. CTGF belongs to the CCN (CTGF/Cyr61/Cef10/NOVH) protein family, which is comprised of six secreted proteins that reside in the extracellular matrix (ECM) . CTGF causes a variety of cellular responses including reduced cell adhesion and enhanced cell migration and proliferation. CTGF has also been shown to be essential for epithelial to mesenchymal transition (EMT), a process whereby normal functioning cells morph into ones that produce mainly scar tissue (of which collagen in the major protein component) .