Recombinant Human Histatin-3/HTN3

Source: E. coli. MW :4.4kD. Recombinant Human Histatin-3 is produced by our E.coli expression system and the target gene encoding Asp20-Asn51 is expressed. Histatin-3 (HTN3) belongs to the histatin/statherin family. Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle) . In addition, histatins exhibit antibacterial and antifungal activities. Post-translational proteolytic processing results in many histatins: e.g., histatins 4-6 are derived from histatin 3 by proteolysis. Histatins 1 and 3 are primary products of HIS1and HIS2 alleles, respectively. Histatins are believed to have important non-immunological, anti-microbial function in the oral cavity. In addition, His3- (20-43) -peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9.