Recombinant Human DNA Polymerase d Subunit 2/POLD2 (C-6His)

Source: E. coli. MW :52.3kD. Recombinant Human DNA Polymerase Delta Subunit 2 is produced by our E.coli expression system and the target gene encoding Met1-Pro469 is expressed with a 6His tag at the C-terminus. DNA Polymerase Delta Subunit 2 (POLD2) belongs to the DNA polymerase delta/II small subunit family. POLD2 can form a heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. POLD2 possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. POLD2 is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA) .