Recombinant Human Aldo-Keto Reductase 1C4/AKR1C4 (N-6His)
Source: E.coli. MW :39.3kD. Recombinant Human Aldo-Keto Reductase 1C4 is produced by our E.coli expression system and the target gene encoding Met1-Tyr323 is expressed with a 6His tag at the N-terminus. Aldo-Keto Reductase 1C4/AKR1C4 is a member of the aldo/keto reductase family that consists of more than 40 known enzymes and proteins. AKR1C4 has highly expressed in Liver. It can catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. AKR1C4 catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-a-Androstan-3-a,17- beta-diol (3-a-diol) . In addition, AKR1C4 also has some 20-a-Hydroxysteroid Dehydrogenase activity.
Product Specifications
Gene Name
AKR1C4
Gene ID
1109
UniProt
P17516
Components
Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.
Shipping Conditions
The product is shipped on dry ice/ice packs.
Storage Conditions
Store at -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
Applications Notes
Endotoxin : Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test.
Amino Acids
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