Recombinant Human Bactericidal Permeability-Increasing Protein/BPI/CAP57 (C-6His)

Source: Human Cells. MW :52.5kD. Recombinant Human CAP57 is produced by our Mammalian expression system and the target gene encoding Val32-Lys487 is expressed with a 6His tag at the C-terminus. Bactericidal permeability-increasing protein (BPI for short), is a secreted protein which belongs to the BPI/LBP/Plunc superfamily, BPI/LBP family. It exists as a monomer or a disulfide-linked homodimer. The cytotoxic action of BPI is limited to many species of Gram-negative bacteria. This specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. BPI has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, and this activity is inhibited by LPS from P.aeruginosa.