Recombinant Mouse Interleukin-5 Receptor Subunit Alpha/IL-5 Ra (C-6His)

Source: Human Cells. MW :37.6kD. Recombinant Mouse Interleukin-5 Receptor Subunit Alpha is produced by our Mammalian expression system and the target gene encoding Asp18-His339 is expressed with a 6His tag at the C-terminus. Interleukin 5 Receptor alpha (IL-5 Ra), also known as CD125, is a hematopoietin receptor that plays a dominant role in eosinophil biology. Mature mouse IL-5 Ra consists of a 322 amino acid (aa) extracellular domain (ECD) with a WSxWS motif and a four cysteine motif, a 22 aa transmembrane segment, and a 54 aa cytoplasmic domain. The high affinity receptor for IL-5 is a complex that consists of the ligand binding IL-5 Ra and the transmembrane common beta chain (betac/CD131) which is shared with the receptor complexes for IL-3 and GM-CSF. IL-5 Ra binds IL-5 at low affinity and then associates with preformed betac oligomers to form the signaling-competent receptor complex. IL-5 stimulation of CD34+ hematopoietic progenitor cells induces the up-regulation of transmembrane IL-5 Ra followed by eosinophilic differentiation and activation. IL-5 Ra also promotes the differentiation of basophils and B cells. Exposure of mature eosinophils to IL-5 attenuates their IL-5 responsiveness by inducing the down-regulation of surface IL-5 Ra and increased production of soluble IL-5 Ra.