Recombinant Human GDNF Family Receptor a-1/GFRA1 (C-6His)

Source: Human Cells. MW :46.28kD. Recombinant Human GDNF Family Receptor alpha-1 is produced by our Mammalian expression system and the target gene encoding Asp25-Lys429 is expressed with a 6His tag at the C-terminus. Glial Cell Line-Derived Neurotrophic Factor Family Receptor a-1 (GDNFRa1) is a glycosylphosphatidylinositol (GPI) linked cell surface protein belonging to GDNF-family receptor a subtype which consists of at least four members. GFRa1and GFRa2 are the cognate co-receptor for the neurotrophic factor neurturin mediating the NRTN-induced autophosphorylation and activation of the RET tyrosine kinase receptor. Soluble GFRas released enzymatically from the cell surface by phosphatidylinositol phospholipase C, as well as recombinantly produced soluble GFRa1, can also bind with high affinity to GDNF and trigger the activation of Ret tyrosine kinase. Human GFRa1 shares 93% amino acid identity with mouse GFRa1.The expression of the various GFRas are differentially regulated in the central and peripheral nervous system, suggesting complementary roles for the GFRas in mediating the activities of the GDNF family of neurotrophic factors.