Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM3/HAVCR2 (C-6His)

Source: Human Cells. MW :20.86kD. Recombinant Human TIM-3 is produced by our Mammalian expression system and the target gene encoding Ser22-Arg200 is expressed with a 6His tag at the C-terminus. T-Cell Membrane Protein 3 (TIM3) is a single-pass type I membrane protein that belongs to the TIM family of immunoglobulin superfamily. TIM3 includes a signal sequence (aa 1-21), an extracellular region (aa 22-202) with one Ig-like V-type domain, a transmembrane segment (aa 203-223), and a cytoplasmic domain (aa 224 - 301) . TIM3 regulates macrophage activation, inhibits T-helper type 1 lymphocyte (Th1) -mediated auto- and alloimmune responses and promotes immunological tolerance. It may be also involved in T-cell homing and as a receptor for LGALS9.