AKT1 Human, Sf9

Source: Sf9, Baculovirus cells.Sterile filtered colorless solution.Akt1, also known as Akt or else protein kinase B (PKB) is an important molecule in mammaliancellular signaling. In humans, there are three genes in the "Akt family": Akt1, Akt2, and Akt3. Moreover, these enzymes are members of the serine/threonine-specific protein kinase family (EC2.7.11.1) . Akt1 is involved in cellular survival pathways, by inhibiting apoptoticprocesses. Akt1 is also able to induce protein synthesis pathways, and is therefore a key signaling protein in the cellular pathways which lead to skeletal muscle hypertrophy, and general tissue growth. Since it can block apoptosis, and thereby promote cell survival, Akt1 has been implicated as a most important factor in numerous types of cancer. Akt (now also called Akt1) was at first identified as the oncogenein the transforming retrovirus, AKT8.AKT1 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 488 amino acids (1-480a.a.) and having a molecular mass of 56.7kDa. (Molecular size on SDS-PAGE will appear at approximately 50-70kDa) . AKT1 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.