SPR Mouse

Source: Escherichia Coli.Sterile filtered colourless solution.Sepiapterin Reductase is an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is essential in the biosynthesis of BH4. Mutations in Sepiapterin Reductase gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Sepiapterin reductase is part of the short-chain dehydrogenase/reductase family which reduces exogenous carbonyl compounds as well as phenylpropanedione. Sepiapterin reductase is an important enzyme for the biosynthesis of tetrahydrobiopterin, an necessary cofactor for aromatic amino acid hydrolases together with tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis.SPR Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 285 amino acids (1-262 a.a) and having a molecular mass of 30.3kDa.SPR is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.