Recombinant Human Tripartite Motif Containing 21 (RO52)

Source : Sf9 insect cells. TRIM21 Human Recombinant produced in SF9 is a glycosylated, polypeptide chain having a calculated molecular mass of 54,922 Dalton. TRIM21 is expressed with a -6x His tag at N-terminus and purified by proprietary chromatographic techniques. TRIM21 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The 52 kDa Ro protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. Ro/SSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Ribonucleoprotein particle is composed of a single polypeptide and one of four small RNA molecules. The RoSSA is present in all mammalian cells studied but has no known function. At least 2 isoforms are present in nucleated and red blood cells, and tissue specific differences in Ro/SSA proteins were identified.