Recombinant Human Transcription Elongation Factor B Polypeptide 2

Source : Escherichia Coli. TCEB2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 118 amino acids (1-118) and having a molecular mass of 13.1 kDa. TCEB2 is purified by standard chromatography techniques. TCEB2 is a subunit of the SIIII complex which is a heterotrimer consisting of a transcriptionally active subunit (A) and two regulatory subunits (B and C) . TCEB2 initiates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.

Product Specifications

Product Name Alternative

ELOB||SIII||Elongin B||Transcription elongation factor B polypeptide 2||RNA polymerase II transcription factor SIII subunit B||SIII p18||Elongin 18 kDa subunit||TCEB2.

Purification

Greater than 95.0% as determined by SDS-PAGE.

Components

The TCEB2 protein solution contains 20mM Tris-HCl pH-8, 1mM DTT, 0.1mM PMSF, and 20% glycerol.

Storage Conditions

TCEB2 although stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) .Please prevent freeze-thaw cycles.