Recombinant Human Small Nuclear Ribonucleoprotein Polypeptides B & B1
Source : Sf9 insect cells. SNRPB Human Recombinant produced in SF9 is a glycosylated, polypeptide chain having a calculated molecular mass of 25,433 Dalton. SNRPB is expressed with a -6x His tag at N-terminus and purified by proprietary chromatographic techniques. SNRPB is one of several nuclear proteins which are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs) . These snRNPs are involved in pre-mRNA splicing, and the SNRPB protein may also have a role in pre-mRNA splicing or snRNP structure. SNRPB binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner. SNRPB functions in the U7 snRNP complex which is involved in histone 3'-end processing.
Product Specifications
Product Name Alternative
Small nuclear ribonucleoprotein-associated proteins B and B'||snRNP-B||Sm protein B/B'||Sm-B/B'||SmB/B'||SNRPB||COD||SNRPB1||SmB/SmB'.
Purification
Greater than 80% as determined by SDS-PAGE.
Components
SNRPB is supplied in 20mM HEPES buffer pH-7.6, 250mM NaCl and 20% glycerol.
Storage Conditions
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.
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