Recombinant Human SH2 domain containing 1A

Source : Escherichia Coli. SH2D1A Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 148 amino acids (1-128 a.a.) and having a molecular mass of 16.3kDa. The SH2D1A is purified by proprietary chromatographic techniques. SH2D1A acts as an inhibitor of the signaling lymphocyte activation molecule (SLAM) self-association. The SH2D1A protein is expressed at a high level in the thymus and the lung, with a lower level of expression in the spleen and the liver. The SH2D1A protein contains an SH2 domain and a short tail. SH2D1A has a key role in the bidirectional stimulation of T and B cells. Defects in the SH2D1A gene cause the X-linked lymphoproliferative disease (XLPD), aka Duncan disease. The XLPD is distinguished by a rare congenital immunodeficiency following an EBV infection (Epstein-Barr virus) .

Product Specifications

Product Name Alternative

SH2 domain-containing protein 1A||Duncan disease SH2-protein||Signaling lymphocytic activation molecule-associated protein||SLAM-associated protein||T-cell signal transduction molecule SAP||SH2D1A||DSHP||SAP||LYP||XLP||EBVS||IMD5||XLPD||MTCP1||FLJ186

Purification

Greater than 95.0% as determined by SDS-PAGE.

Components

The SH2D1A solution (1 mg/mL) contains 20mM Tris-HCl Buffer (pH 7.5), 1mM DTT and 10% Glycerol.

Storage Conditions

SH2D1A should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) . Please prevent freeze-thaw cycles.

Amino Acids

MGSSHHHHHH SSGLVPRGSH MDAVAVYHGK ISRETGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYHGY IYTYRVSQTE TGSWSAETAP GVHKRYFRKI KNLISAFQKP DQGIVIPLQY PVEKKSSARS TQGTTGIRED PDVCLKAP.