Recombinant Human Pregnancy Specific Beta-1-Glycoprotein 1

Source : Escherichia Coli. PSG1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 408 amino acids (35-419) and having a molecular mass of 45.9 kDa.PSG1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Pregnancy Specific Beta-1-Glycoprotein 1 (PSG1) is a member of a subgroup of transcription factors which are phosphorylated upon binding to promoter sequences. PSGs belong to the carcinoembryonic antigen (CEA) family and function as early biochemical markers of syncytiotrophoblast formation. Furthermore, PSG1 is assumed to mediate placental vascular morphogenesis by enhancing VEGF-A production and endothelial tube formation. PSG1 is a major product of the syncytiotrophoblast, reaching concentrations of 100- 290 mg/l at term in the serum of pregnant women.