Recombinant Human Polyglutamine Binding Protein 1

Source : E.coli. PQBP1 Human Recombinant produced in E. coli is a single polypeptide chain containing 289 amino acids (1-265) and having a molecular mass of 33.0kDa.PQBP1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. PQBP1 is a transcription repressor which is connected to polyglutamine tract-containing transcription regulators and connective genes for neurodegenerative disorders. PQBP1 is restricts to the nucleus and can be found in neurons all over the brain, with high levels in hippocampus, olfactory bulb and cerebellar cortex. PQBP1 holds a WWP/WW domain that binds proline-rich motifs and a C2 domain which is able to stimulate Ca2+-dependent phospholipid signaling.