Recombinant Human Programmed Cell Death 1 Ligand 2

Source : E.coli. PDCD1LG2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 204 amino acids (20-200 a.a.) and having a molecular mass of 22.8kDa.PDCD1LG2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Programmed cell death 1 ligand 2 (PDCD1LG2) which takes part in the costimulatory signal, is necessary for T-cell proliferation. PDCD1LG2 is also involved in IFNG production in a PDCD1-independent way. The interaction with PDCD1 inhibits T-cell proliferation by preventing cytokine production and cell cycle progression.

Product Specifications

Product Name Alternative

Programmed cell death 1 ligand 2||PD-1 ligand 2||PD-L2||PDCD1 ligand 2||Programmed death ligand 2||PDCD1LG2||B7-DC||Butyrophilin B7-DC||CD273||B7DC||CD273||PDCD1L2||PDL2||bA574F11.2||Btdc.

Purification

Greater than 90% as determined by SDS-PAGE.

Components

PDCD1LG2 protein solution (1mg/mL) containing 20mM Tris-HCl buffer (pH8.0), 0.4M Urea and 10% glycerol.

Storage Conditions

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) .Avoid multiple freeze-thaw cycles.

Amino Acids

MGSSHHHHHH SSGLVPRGSH MGSLFTVTVP KELYIIEHGS NVTLECNFDT GSHVNLGAIT ASLQKVENDT SPHRERATLL EEQLPLGKAS FHIPQVQVRD EGQYQCIIIY GVAWDYKYLT LKVKASYRKI NTHILKVPET DEVELTCQAT GYPLAEVSWP NVSVPANTSH SRTPEGLYQV TSVLRLKPPP GRNFSCVFWN THVR.