Recombinant Human Myxovirus Resistance 2

Source : Escherichia Coli. MX2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 126 amino acids (626-715) and having a molecular mass of 14.9 kDa. MX2 is fused to a 36 amino acid His-tag at N-terminus. MX2 is a member of 2 protein families: the dynamin family and the large GTPases family. MX2 has a cytoplasmic and nuclear structure which is found in a granular pattern in the heterochromatin region under the nuclear envelope. The nuclear form has a NLS (nuclear localization signal) at the amino terminal end however it is missing in the cytoplasmic form as a result of the use of a different translation start codon. MX2 is upregulated by IFN-a, but unlike myxovirus resistance protein 1 has no antiviral activity.

Product Specifications

Product Name Alternative

Myxovirus (Influenza Virus) Resistance 2 (Homolog Of Mouse) ||Interferon-Regulated Resistance GTP-Binding Protein MxB||Second Interferon-Induced Protein P78||Myxovirus Resistance Protein 2||Human Interferon-Regulated Resistance GTP-Binding Protein MXB

Purification

Greater than 90% as determined by SDS-PAGE.

Components

The MX2 solution (1mg/mL) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.

Storage Conditions

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) .Avoid multiple freeze-thaw cycles.