Recombinant Human Mesenchyme Homeobox 2

Source : Escherichia Coli. MEOX2 Human Recombinant produced in E. coli is a single polypeptide chain containing 140 amino acids (188-304) and having a molecular mass of 15.9kDa. MEOX2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Homeobox protein MOX-2 (MEOX2) is a part of a family of nonclustered, diverged homeobox genes which are expressed in overlapping patterns in the paraxial mesoderm and its derivatives. MEOX2 participates in the regulation of vertebrate limb myogenesis. MEOX2 also takes part in mesoderm induction and its earliest regional specification, somitogenesis, myogenic and sclerotomal differentiation. Mutations in the related mouse MEOX2 are related with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease.