Recombinant Human Junctional Adhesion Molecule 3

Source : E.coli. JAM3 Human Recombinant produced in E. coli is a single polypeptide chain containing 234 amino acids (32-241) and having a molecular mass of 26.0 kDa.JAM3 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. JAM3 belongs to the junctional adhesion molecule protein family and functions as a receptor for another member of this family. JAM3 plays a part in cell-cell adhesion. The soluble form of JAM3 is a mediator of angiogenesis. JAM3 is a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN) . A mutation in an intron of the JAM3 gene is linked with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts.