CHP1 Recombinant Protein

Source : Escherichia Coli. CHP Recombinant E.coli produced in E.Coli is a single, non-glycosylated polypeptide chain containing 216 amino acids (1-195 a.a.) and having a molecular mass of 24.7 kDa. The CHP is fused to 21 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques. Calcium-binding protein P22 is a phosphoprotein that binds to the sodium-hydrogen exchangers (NHEs) . CHP is an essential cofactor which maintains the physiological activity of NHE family members. CHP has protein sequence resemblance to calcineurin B and it is also identified to be an endogenous inhibitor of calcineurin activity.CHP is necessary for constitutive membrane traffic. CHP Inhibits GTPase-stimulated Na (+) /H (+) exchange. CHP inhibits calcineurin phosphatase activity. Required for activity of SLC9A1/NHE1.