PL 12 Recombinant Protein
Source : Sf9 insect cells. Alanyl-tRNA synthetase Human Recombinant produced in SF9 is a glycosylated, polypeptide chain having a molecular mass of 107,598 Dalton. PL-12 is expressed with a -6xHis tag and purified by proprietary chromatographic techniques. Alanyl-tRNA synthetase is a member of the aminoacyl-tRNA synthetase family, key enzymes of protein biosynthesis which charge tRNA molecules with the respective amino acids. This 108 kDa protein is an autoantigen recognized by PL-12 antibodies which occur in a subset of patients with polymyositis and dermatomyositis. Preliminary data suggest that epitope spreading occurs in the autoimmune PL-12 response such that even antibodies to an isolated alanyl-tRNA molecule can develop.
Product Specifications
Product Name Alternative
Alanyl-tRNA synthetase cytoplasmic||EC 6.1.1.7||Alanine-tRNA ligase||AlaRS||Renal carcinoma antigen NY-REN-42||PL-12||AARS.
Purification
Greater than 90% as determined by SDS-PAGE.
Components
PL-12 is supplied in16mM HEPES buffer pH-8, 250mM sodium chloride, and 20% glycerol.
Storage Conditions
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.
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