OTC Recombinant Protein
Source : E.coli. OTC Recombinant produced in E. coli is a single polypeptide chain containing 347 amino acids (33-354) and having a molecular mass of 38.9kDa.OTC is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. OTC is a member of the ATCase/OTCase family. OTC has a key part in the urea cycle, catalyzing the second step in this pathway: the transformation of L-orthinine and carbamoyl phosphate to L-citrulline. In humans, the urea cycle is a vital pathway to detoxification of ammonia. Alterations in the gene encoding OTC are linked to the X-linked disorder OTCD (ornithine carbamoyltransferase deficiency) . OTCD disorder of the urea cycle is characterized by hyperammonemia.
Product Specifications
Product Name Alternative
Ornithine carbamoyltransferase mitochondrial||Ornithine transcarbamylase||OTCase||OCTD||EC 2.1.3.3.
Purification
Greater than 90% as determined by SDS-PAGE.
Components
The OTC solution (0.5mg/mL) contains 20mM MES buffer (pH 6.0), 100mM Nacl, 2mM DTT and 10% glycerol.
Storage Conditions
Amino Acids
Frequently Asked Questions
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