MMP 3 Recombinant Protein
Source : Escherichia Coli. MMP 3 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 401 amino acids (100-477a.a) and having a molecular mass of 45.2kDa. MMP 3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. MMP-3 enzyme is also known as Stromelysin-1or as Transin-1 which hydrolyzes natural collagen at physiological pH and temperature. It dissolves the intervertebral nucleus pulposus and annulus fibrosus of Herniated Lumbar Intervertebral Disk . MMP-3 hydrolyzes components of the extracellular matrix like proteoglycan, laminin, fibronectin, gelatin and collagen types III, IV and IX. It also activates pro-MMP-9 and pro-MMP-8 and superactivates plasmin activated MMP-1. MMP-3 is secreted as a latent proenzyme and is activated by a variety of proteinases, e.g. plasmin, trypsin, chymotrypsin, cathepsin G or human neutrophil elastase. MMP-3 was found to be capable of activating the precursor of IL1-beta.
Product Specifications
Product Name Alternative
CHDS6||MMP-3||SL-1||STMY||STMY1||STR1||Stromelysin-1||Matrix metalloproteinase-3||Transin-1||MMP3.
Purification
Greater than 90% as determined by SDS-PAGE.
Components
The MMP 3 solution (0.25mg/mL) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, and 10% glycerol.
Storage Conditions
Amino Acids
Frequently Asked Questions
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